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PSYCHIATRIC GRAND ROUNDS
May 7, 2008

 

Title:

Celebrating National Nurses’ Recognition Week
Linking Neurobiological Findings to Prescriptive Practice for Common Psychiatric Disorders

Presenter:

Susan McCabe, Ed.D., APRN, CS, Associate Professor, Fay W. Whitney School of Nursing, University of Wyoming, Laramie, WY

Location:

Hartford Room, The Commons Building, 2nd Floor, The Institute of Living/Hartford Hospital
200 Retreat Avenue, Hartford, CT 06106

Abstract:

Vast amounts of information about the workings of the brain and psychiatric disorders have been compiled over the past two decades. This information is opening up new approaches to assessment, treatment, and ongoing clinical management of patients with psychiatric disorders. This presentation presents an overview of the emergent neurobiological principles that should influence cutting edge prescriptive practices for patients experiencing common psychiatric disorders. Content will address new understanding of such things as soft neurological signs, cortical plasticity, hierarchical structuring, and brain neurotrophic factors. The links between this content and the selection of medications for optimal treatment will be discussed, along with the rational for the development of  many new psychiatric treatments, and the implications of this knowledge to the APN role. Participants will leave this presentation with a clear idea of how to apply and utilize neurobiological principles in every day care practice settings.

Learning Objectives:

  • The participants will be able to identify the critical principles of advance neurobiology needed for prescriptive clinical practice.

  • The participants will be able to  analyze the role of neurotransmitters and brain structures in the behavioral expression of mental illness.

  • The participants will be able to  discuss the implications for prescriptive practice of new brain findings.

References:

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Sigmundsson T, Suckling J, Maier M, et al. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am J Psychiatry. Feb 2001;158(2):234-43. 

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American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). 4th ed. Washington, DC: American Psychiatric Press; 2000.

Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan M, et al. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry. Aug 2004;61 (8):774-80.

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Bibliography prepared by the IOL Medical Library.  Call 545-7276 for information.

 

Books

Clark DL et al.  The Brain and Behavior: An Introduction to Behavioral Neuroanatomy.  Cambridge University Press, 2005.  WL 300 C592b.

Stahl SM.  Essential Psychopharmacology: Neuroscientific Basis and Practical Applications, Second Edition.  Cambridge University Press, 2000.  WM 402 S781e.

 

Articles

<1>  Howland RH.  Glutamate-modulating drugs & the treatment of mental disorders. [Review] [33 refs]  Journal of Psychosocial Nursing & Mental Health Services.  45(1):11-4, 2007 Jan.

<2>  Askland K.  Parsons M.  Toward a biaxial model of "bipolar" affective disorders: spectrum phenotypes as the products of neuroelectrical and neurochemical alterations. [Review] [190 refs]  Journal of Affective Disorders.  94(1-3):15-33, 2006 Aug.

<3>  Howland RH.  Personalized drug therapy with pharmacogenetics--part 2: pharmacodynamics. [Review] [17 refs]  Journal of Psychosocial Nursing & Mental Health Services.  44(2):13-6, 2006 Feb.

<4>  Arnsten AF.  Li BM.  Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. [Review] [95 refs]  Biological Psychiatry.  57(11):1377-84, 2005 Jun 1.

<5>  Keltner NL.  Kelley FJ.  The ABCs of psychopharmacology.  Perspectives in Psychiatric Care.  39(4):169-73, 2003 Oct-Dec.  (ELECTRONIC FULL-TEXT FORMAT)

<6>  Stahl SM et al.  Brain circuits determine destiny in depression: a novel approach to the psychopharmacology of wakefulness, fatigue, and executive dysfunction in major depressive disorder. [Review] [194 refs]  Journal of Clinical Psychiatry.  64 Suppl 14:6-17, 2003.

<7>  Stahl SM.  Deconstructing psychiatric disorders, part 2: An emerging, neurobiologically based therapeutic strategy for the modern psychopharmacologist.  Journal of Clinical Psychiatry.  64(10):1145-6, 2003 Oct.

<8>  Greenshaw AJ.  Neurotransmitter interactions in psychotropic drug action: beyond dopamine and serotonin.  Journal of Psychiatry & Neuroscience.  28(4):247-50, 2003 Jul.

<9>  Mohr WK.  Mohr BD.  Brain, behavior, connections and implications: psychodynamics no more. [Review] [83 refs]  Archives of Psychiatric Nursing.  15(4):171-81, 2001 Aug.


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