PSYCHOPHARMACOLOGY/NEUROSCIENCE ROUNDS
May 29, 2008
Title:
Mild Cognitive Impairment:
Identification and Treatment
Presenter:
Mo Juin Yong M.D., PGY4,
Psychiatry Residency Program, The Institute
of Living/Hartford Hospital
Location:
Hartford Room, The Commons Building, 2nd
Floor, The Institute of Living/Hartford Hospital
200 Retreat Avenue, Hartford, CT 06106
Abstract:
The concept of mild
cognitive impairment (MCI) has received a lot of interest during the past few
years, especially as a possible transitional period between normal ageing and
dementia. Due to the worldwide ageing phenomenon, dementia and MCI have
emerging public health importance. Therefore, the concept of MCI is useful both
clinically and as a research entity. However, there is still confusion regarding
this concept and controversies pertaining to its definition, assessment,
management and intervention strategies. This presentation will attempt to
address these issues surrounding the concept of mild cognitive impairment.
Learning
Objectives:
After attending the
presentation, the participants will be able to:
Discuss the concept of MCI in terms of its definition and
diagnostic criteria.
Describe the clinical presentation
and outcome of MCI patients.
List the cognitive markers,
biomarkers, neuroimaging, and genetics seen in MCI.
List the recommendations for
management of MCI patients.
Discuss the future research in MCI.
References:
Winblad B, Palmer K, Kivipelto M, Jelic V, and
Fratiglioni. Introduction: mild cognitive impairment, beyond controversies
towards a consensus. Journal of Internal Medicine. 2004;
256:181-182.
Petersen RC. Mild cognitive impairment as a
diagnostic entity. Journal of Internal Medicine. 2004; 256: 183-194.
Winblad B, Palmer K, et al. Mild cognitive
impairment: beyond controversies, toward a consensus: report of international
working group on mild cognitive impairment. Journal of Internal Medicine.
2004; 245: 240-246.
Brendan JK, Petersen RC. Alzheimer’s disease
and mild cognitive impairment. Neurologic Clinics. 2007; 25:
577-609.
Petersen R. Aging, mild cognitive impairment
and Alzheimer’s disease. Neurologic Clinics. 2000; 18.
Backman
L, Jones S, Berger AK, Laukka J, and Small BJ. Multiple cognitive deficits
during the transition to Alzheimer’s disease. Journal of Internal
Medicine. 2004; 256: 195-204.
Leon
MJ, Desanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Clark C, et al.
MRI and CSF studies in the early diagnosis of Alzheimer’s disease. Journal
of Internal Medicine. 2004; 245: 205-223.
Blennow K. CSF biomarkers for mild cognitive
impairment. Journal of Internal Medicine. 2004; 256:224-234.
Van Duijn CM.
Prospects of genetic research of mild cognitive impairment. Journal of
Internal Medicine. 2004; 256: 235-239.
Fleisher AS, Sun S, Taylor C, Ward CP, Gamst AC,
Petersen RC. Volumetric MRI vs clinical predictors of Alzheimer’s disease
in mild cognitive impairment. Neurology. 2008; 70 (3): 191-199.
Dickerson BC, Sperling RA, Hyman BT, Albert MS,
Blacker D. Clinical Prediction of Alzheimer’s disease dementia across
spectrum of mild cognitive impairment. Archives of General Psychiatry.
2007; 64(12): 1443-1450.
Blacker D, Lee H, Muzikansky A, Martin EC, Tanzi R.
Neuropsychological measures in normal individuals that predict subsequent
cognitive decline. Archives of Neurology. 2007; 64(6): 862-871.
Targum SD. Biomarkers for the identification
and treatment of dementia. Psychiatry. 2008; 5(2); 51-56.
Bibliography prepared
by the IOL Medical Library. Call 545-7276 for information.
Books
Weiner MF & Lipton AM.
The Dementias: Diagnosis, Treatment, and Research, Third Edition. American
Psychiatric Publishing, 2003. WM 220 D3765.
Articles
<1> Whitwell JL et al.
MRI patterns of atrophy associated with progression to AD in amnestic mild
cognitive impairment. Neurology. 70(7):512-20, 2008 Feb 12.
(ELECTRONIC FULL-TEXT FORMAT)
<2> Fleisher AS et al.
Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive
impairment. Neurology. 70(3):191-9, 2008 Jan 15.
(ELECTRONIC FULL-TEXT FORMAT)
<3> Smith EE et al.
Magnetic resonance imaging white matter hyperintensities and brain volume in the
prediction of mild cognitive impairment and dementia. Archives of Neurology.
65(1):94-100, 2008 Jan. (ELECTRONIC
FULL-TEXT FORMAT)
<4> Dickerson BC et al.
Clinical prediction of Alzheimer disease dementia across the spectrum of mild
cognitive impairment. Archives of General Psychiatry. 64(12):1443-50, 2007
Dec.
<5> Whitwell JL et al.
Patterns of atrophy differ among specific subtypes of mild cognitive
impairment. Archives of Neurology. 64(8):1130-8, 2007 Aug.
(ELECTRONIC FULL-TEXT FORMAT)
<6> Kelley BJ. Petersen
RC. Alzheimer's disease and mild cognitive impairment. [Review] [200 refs]
Neurologic Clinics. 25(3):577-609, v, 2007 Aug.
(ELECTRONIC FULL-TEXT FORMAT)
<7> Petersen RC et al.
Neuropathologic features of amnestic mild cognitive impairment. Archives of
Neurology. 63(5):665-72, 2006 May.
(ELECTRONIC FULL-TEXT FORMAT)
<8> Gauthier S et al.
Mild cognitive impairment. [Review] [96 refs] Lancet. 367(9518):1262-70, 2006
Apr 15. (ELECTRONIC FULL-TEXT FORMAT)
<9> Steffens DC et al.
Perspectives on depression, mild cognitive impairment, and cognitive decline.
Archives of General Psychiatry. 63(2):130-8, 2006 Feb.
<10> Dickerson BC et al.
Increased hippocampal activation in mild cognitive impairment compared to normal
aging and AD. Neurology. 65(3):404-11, 2005 Aug 9. (ELECTRONIC FULL-TEXT
FORMAT
<11> Petersen RC. Mild
cognitive impairment as a diagnostic entity. [Review] [50 refs] Journal of
Internal Medicine. 256(3):183-94, 2004 Sep. (ELECTRONIC FULL-TEXT FORMAT
<12> Arnaiz E et al. Mild
cognitive impairment: a cross-national comparison. Journal of Neurology,
Neurosurgery & Psychiatry. 75(9):1275-80, 2004 Sep.
Top
| 
